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J Am Chem Soc. 2005 Jul 6;127(26):9320-1.

Fluorescent profiling of natural product producers.

Author information

1
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.

Abstract

The identification of natural product producer organisms remains a problem for both isolation and natural product classification. A concise screen is developed through fluorescent modification of a set of natural products that offer a common activity. Through real-time multicolor microscopy, the processing, storage, and effects of a natural product are rapidly screened at the level of the strain and individual organism.

PMID:
15984830
DOI:
10.1021/ja042756u
[Indexed for MEDLINE]
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