[Changes of the concentration of lipid peroxidation products and thiol groups in rat brains with long-term intoxication with methanol]

Arch Med Sadowej Kryminol. 2005 Jan-Mar;55(1):39-41.
[Article in Polish]

Abstract

The aim of this paper was to define the influence of long-term methanol intoxication on the changes of end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-group concentration in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar methanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, which encompassed measurement of the concentration of TBA-reactive products and free SH-groups. The revealed changes of TBA-reactive products and free SH-group concentration were not statistically significant.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism*
  • Brain Chemistry
  • Lipid Peroxidation / drug effects*
  • Male
  • Methanol / toxicity*
  • Oxidative Stress / drug effects
  • Random Allocation
  • Rats
  • Rats, Inbred Lew
  • Sulfhydryl Compounds / metabolism*
  • Thiobarbiturates / chemistry
  • Time Factors

Substances

  • Sulfhydryl Compounds
  • Thiobarbiturates
  • thiobarbituric acid
  • Methanol