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Zhong Yao Cai. 2005 Feb;28(2):117-9.

[Effect of ginsenoside Rg1 on neprilysin expression induced by LPS in SK-N-SH cell line].

[Article in Chinese]

Author information

1
Jinan University, Guangzhou 510632.

Abstract

OBJECTIVE:

To investigate the effect of ginsenoside Rg1 on the neprilysin (NeP) expression induced by LPS in SK-N-SH cell line.

METHODS:

MTT was used to measure the survival rate of SK-N-SH cultured with ginsenoside Rg1 at different concentrations (5, 10, 20 micromol/L) and LPS (50 mg/L). The expression of NEP was measured by RT-PCR.

RESULT:

The survival rate of SK-N-SH was obviously inhibited by LPS, the expression of NEP was decreased. On the other hand, the above alteration induced by LPS was reversed by ginsenoside Rg1.

CONCLUSION:

This study demonstrates that LPS can cause cell damage and the decrease of NEP expression. Ginsenoside Rg1 can protect SK-N-SH cells against the injury induced by LPS, increase NEP expression.

PMID:
15981886
[Indexed for MEDLINE]

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