Format

Send to

Choose Destination
Gastroenterol Clin Biol. 2005 May;29(5):573-6.

Usefulness of specific IgG avidity for diagnosis of hepatitis A infection.

Author information

1
Centre National de Référence pour les virus à transmission entérique, Laboratoire de Virologie, Hôpital Paul Brousse, Villejuif.

Abstract

AIM:

Diagnosis of acute hepatitis A virus (HAV) infection is classically based on the detection of HAV-IgM. Nevertheless, HAV-IgM can be positive for patients with polyclonal stimulation of their immune system (i.e. immune reactivation). To improve the diagnostic yield, an avidity test for HAV-IgG antibodies was developed and tested.

METHODS:

Avidity tests were performed in 128 sera: 11 selected samples from patients with past infection, 15 acute hepatitis A, 10 vaccinated subjects and 4 patients with immune reactivation as well as 84 HAV-IgM positive unselected sera, provided by routine laboratories.

RESULTS:

Patients with past infection had avidities over 70%, whereas avidities in patients with acute hepatitis A were below 50% during the first month following the onset of symptoms. As expected, patients with immune reactivation had avidities over 70% consistent with past infection. The results obtained for the 84 unselected sera allowed reconsidering the diagnosis of acute hepatitis A for nearly a third of patients.

CONCLUSION:

This test could improve the diagnosis of acute hepatitis A infection, particularly in elderly patients.

PMID:
15980754
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Masson (France)
Loading ...
Support Center