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Antimicrob Agents Chemother. 2005 Jul;49(7):3028-30.

Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis.

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1
Infectious Diseases Research Laboratory, Infectious Diseases Division, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. jgavalda@vhebron.net

Abstract

The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.

PMID:
15980392
PMCID:
PMC1168712
DOI:
10.1128/AAC.49.7.3028-3030.2005
[Indexed for MEDLINE]
Free PMC Article
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