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Antimicrob Agents Chemother. 2005 Jul;49(7):2979-82.

Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6'-N-acetyltransferase type Ib encoded by plasmid pJHCMW1.

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  • 1Department of Biological Science, School of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California 92834-6850, USA.

Abstract

Alanine scanning of motif A in the pJHCMW1-encoded aminoglycoside 6'-N-acetyltransferase type Ib identified amino acids important for the ability of the enzyme to confer wild-type levels of resistance to kanamycin and amikacin. The replacement of two amino acids, D117 or L120, with alanine residues resulted in complete loss of the resistance phenotype.

PMID:
15980378
PMCID:
PMC1168681
DOI:
10.1128/AAC.49.7.2979-2982.2005
[PubMed - indexed for MEDLINE]
Free PMC Article

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