Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9685-90. Epub 2005 Jun 24.

Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping.

Author information

1
Center for Imaging Science, The Whiting School of Engineering, The Johns Hopkins University, 301 Clark Hall, Baltimore, MD 21218, USA. mim@cis.jhu.edu

Abstract

The functional magnetic resonance imagery responses of declarative memory tasks in the medial temporal lobe (MTL) are examined by using large deformation diffeomorphic metric mapping (LDDMM) to remove anatomical variations across subjects. LDDMM is used to map the structures of the MTL in multiple subjects into extrinsic atlas coordinates; these same diffeomorphic mappings are used to transfer the corresponding functional data activation to the same extrinsic coordinates. The statistical power in the averaged LDDMM mapped signals is significantly increased over conventional Talairach-Tournoux averaging. Activation patterns are highly localized within the MTL. Whereas the present demonstration has been aimed at enhancing alignment within the MTL, this technique is general and can be applied throughout the brain.

PMID:
15980148
PMCID:
PMC1172268
DOI:
10.1073/pnas.0503892102
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center