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FEMS Microbiol Lett. 2005 Jul 15;248(2):147-52.

Identification of genetic markers for Mycobacterium pinnipedii through genome analysis.

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1
Institute of Biotechnology, CICVyA-INTA, 1712 Castelar, Argentina. fbigi@cicv.inta.gov.ar

Abstract

Tuberculosis in seals is caused by Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray-based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii: PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised.

PMID:
15979818
DOI:
10.1016/j.femsle.2005.05.034
[Indexed for MEDLINE]
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