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Curr Opin Genet Dev. 2005 Aug;15(4):410-5.

MicroRNAs in vertebrate development.

Author information

  • 1Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, PO Box 100266, Gainesville, FL 32610, USA. bharfe@mgm.ufl.edu

Abstract

The vertebrate genome contains hundreds of small non-coding 'microRNAs' that have been implicated in controlling the expression of potentially thousands of target genes. Presently, only a handful of these targets have been characterized. Recent reports of microRNA 'sensors', microRNA microarrays and the creation of vertebrates that lack all microRNA activity will aid in determining the roles played by microRNAs, and the genes that they regulate, during vertebrate development.

PMID:
15979303
DOI:
10.1016/j.gde.2005.06.012
[PubMed - indexed for MEDLINE]
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