Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2005 Aug;28(8):422-8.

For K+ channels, Na+ is the new Ca2+.

Author information

1
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Science, The State University of New York, Buffalo, NY 14214, USA.

Abstract

Although K+ channels activated by Ca2+ have long been known to shape neuronal excitability, evidence is accumulating that K+ channels sensitive to intracellular Na+, termed K(Na) channels, have an equally significant role. K(Na) channels contribute to adaptation of firing rate and to slow afterhyperpolarizations that follow repetitive firing. In certain neurons, they also appear to be activated by Na+ influx accompanying a single spike. Two genes encoding these channels, Slick and Slack, are expressed throughout the brain. The spatial localization of K(Na) channels along axons, dendrites and somata appears to be highly cell-type specific. Their molecular properties also suggest that these channels contribute to the response of neurons to hypoxia.

PMID:
15979166
DOI:
10.1016/j.tins.2005.06.003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center