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Trends Pharmacol Sci. 2005 Aug;26(8):385-7.

A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1).

Author information

1
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA. ambudkar@helix.nih.gov

Abstract

Intercellular transfer of proteins is a mode of communication between cells that is crucial for certain physiological processes. Chemotherapy is the treatment of choice for approximately 50% of all cancers. However, multidrug resistance mediated by drug-efflux pumps such as P-glycoprotein (Pgp) minimizes the effectiveness of such therapy in a large number of patients. A new study demonstrates the functional intercellular transfer of Pgp. Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits.

PMID:
15978680
PMCID:
PMC1350964
DOI:
10.1016/j.tips.2005.06.001
[Indexed for MEDLINE]
Free PMC Article

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