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Dent Clin North Am. 2005 Jul;49(3):551-71, vi.

Diagnostic biomarkers for oral and periodontal diseases.

Author information

1
Department of Periodontics/Prevention/Geriatrics, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA.

Abstract

This article provides an overview of periodontal disease diagnosis that uses clinical parameters and biomarkers of the disease process.This article discusses the use of biomarkers of disease that can be identified at the tissue, cellular, and molecular levels and that are measurable in oral fluids such as saliva and gingival crevicular fluid. Biomarkers identified from these biologic fluids include microbial, host response, and connective tissue-related molecules that can target specific pathways of local alveolar bone resorption. Future prospects for oral fluid-based diagnostics that use micro-array and microfluidic technologies are presented.

PMID:
15978241
PMCID:
PMC2580776
DOI:
10.1016/j.cden.2005.03.009
[Indexed for MEDLINE]
Free PMC Article

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