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J Mol Med (Berl). 2005 Aug;83(8):596-600. Epub 2005 Jun 23.

Bmi1 in development and tumorigenesis of the central nervous system.

Author information

1
Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, 8091 Z├╝rich, Switzerland.

Abstract

The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.

PMID:
15976916
DOI:
10.1007/s00109-005-0682-0
[Indexed for MEDLINE]

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