Format

Send to

Choose Destination
J Am Acad Dermatol. 1992 Apr;26(4):585-9.

Lack of predictive factors for the clinical course of bullous pemphigoid.

Author information

1
Department of Dermatology, Slade Hospital, Oxford, United Kingdom.

Abstract

BACKGROUND:

Bullous pemphigoid is a clinically heterogeneous disease although little is known of the factors affecting its course and outcome.

OBJECTIVE:

Our purpose was to document the clinical course, outcomes, and causes of death in treated bullous pemphigoid and to determine the predictive factors affecting outcome.

METHODS:

The clinical course was documented in 82 patients with immunologically proven bullous pemphigoid (mean follow-up 3 years 2 months). To identify factors predictive of outcome, 16 patients with "good prognosis bullous pemphigoid" (no systemic treatment or in remission within 2 years) were compared with 12 patients with recurrent disease requiring maintenance therapy who still needed treatment after 3 years or longer. Remission was defined as 3 months free of lesions, without systemic treatment.

RESULTS:

The disease duration varied from 9 weeks to 17 years (estimated median treatment time 2 years 1 month). Of patients followed up for at least 2 years, 30% achieved remission and by 3 years the remission rate was 50%. Two patients had a subsequent relapse (9%). The mortality rate at 1 year was 19%, and treatment was believed to be contributory in seven deaths. No clinical, immunologic, or immunogenetic factors were predictive of disease duration.

CONCLUSION:

Despite the heterogeneity of the clinical course and duration of bullous pemphigoid, no predictive factors are recognized.

PMID:
1597545
DOI:
10.1016/0190-9622(92)70085-t
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center