Send to

Choose Destination
Nutr Rev. 2005 May;63(5):166-70.

The mechanism and regulation of fat mobilization from adipose tissue: desnutrin, a newly discovered lipolytic enzyme.

Author information

Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA.


A new member of a family of proteins functioning in the regulation of lipolysis in adipose tissue has been discovered and named "desnutrin." Desnutrin is transiently induced by fasting and decreased by re-feeding. A close homolog, termed adiponutrin, has the opposite expression pattern, being induced by feeding and disappearing upon fasting. Desnutrin functions by acting as the first enzyme in lipolysis, hydrolyzing triglycerides to diglycerides, whereas the well-known hormone-sensitive lipase takes the diglycerides to monoglycerides and on to free fatty acids.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center