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Am J Obstet Gynecol. 2005 Jun;192(6):2047-52; discussion 2053-4.

Evaluation of the pregnancy prolongation index (PPI) as a measure of success of obstetric interventions in the prevention of preterm birth and associated morbidities.

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1
Department of Obstetrics and Gynecology, California-Pacific Medical Center, San Francisco, 94118, USA. funglammd@aol.com

Abstract

OBJECTIVE:

This study was undertaken to evaluate the validity of the pregnancy prolongation index (PPI) as a measure of preterm labor treatment success.

STUDY DESIGN:

Analysis of prospectively collected maternal and neonatal data from a national clinical database (Matria Healthcare). Included were patients with singleton, twin, and triplet pregnancies who had outpatient surveillance initiated between 18 and 34 weeks and delivered at 24 to 36 6/7 weeks' gestation with NICU admission. Each patient's PPI score was calculated via the following equation: [(gestational age at delivery - gestational age at start of treatment) / (37.0 - gestational age at start of treatment)] x 100%. The impact of increasing PPI score was measured against NICU length of stay as a surrogate gauge of neonatal morbidity. Data were further stratified by gestational type and reason for delivery.

RESULTS:

Pregnancy outcomes of 12,642 patients (6,642 singletons, 4,326 twins, and 1,674 triplets) were analyzed. The PPI score increased in a direct, inverse linear relationship with decreasing number of NICU days.

CONCLUSION:

The PPI is a sensitive measure for the evaluation of treatment success in the inhibition of preterm labor and delivery.

PMID:
15970893
DOI:
10.1016/j.ajog.2005.02.034
[Indexed for MEDLINE]
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