Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2005 Jun;192(6):1905-12; discussion 1912-5.

Cost-effectiveness analysis of prenatal population-based fragile X carrier screening.

Author information

1
Department of Obstetrics and Gynecology, California Pacific Medical Center, San Francisco, USA.

Abstract

OBJECTIVE:

To investigate the cost-effectiveness of a widespread prenatal population-based fragile X carrier screening program.

STUDY DESIGN:

A decision tree was designed comparing screening versus not screening for the fragile X mental retardation protein 1 premutation in all pregnant women. Baseline values included a prevalence of fragile X mental retardation protein 1 premutations of 3.3 per 1000, a premutation expansion rate of 11.3%, and a 99% sensitivity of the screening test. The cost of the screening test was varied from 75 US dollars to 300 US dollars. A sensitivity analysis of the probabilities, utilities, and costs was performed.

RESULTS:

The screening strategy would lead to the identification of 80% of the fetuses affected by fragile X annually. Assuming the cost of 95 US dollars per test and only one child, the program would be cost effective at 14,858 US dollars per quality-adjusted life-year. The screening strategy remained cost effective up to 140 US dollars per test and 1 child per woman or for 2 children per woman up to a cost of 281 US dollars per test.

CONCLUSION:

Population-based screening for the fragile X premutation may be both clinically desirable and cost effective. Prospective pilot studies of this screening modality are needed in the prenatal setting.

PMID:
15970847
DOI:
10.1016/j.ajog.2005.02.052
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center