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Cell Cycle. 2005 Jul;4(7):914-8. Epub 2005 Jul 5.

TRAIL: at the center of drugable anti-tumor pathways.

Author information

1
Department of Cell Biology and Signal Transduction, Institut de Génétique et de Biologie Moléculaire et Cellulaire/CNRS/INSERM/ULP, Illkirch Cedex, C. U. de Strasbourg, France.

Abstract

Molecular analysis, in vivo and in vitro has identified TRAIL as a central component of anti-cancer networks in the cell. More recently, TRAIL has been shown to be involved in the selective apoptosis of AML cells by histone deacetylase inhibitors (HDACi). Here we summarize findings that the TRAIL pathway is a key factor in the apoptotic action of HDACi, as well as, retinoids and retinoid-combinations.

PMID:
15970670
DOI:
10.4161/cc.4.7.1822
[Indexed for MEDLINE]

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