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Front Biosci. 2005 Sep 1;10:3078-92.

Transglutaminase and diseases of the central nervous system.

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1
UPR 2228 CNRS, Institut Interdisciplinaire des Sciences du Vivant, Université René Descartes, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France.

Abstract

Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.

PMID:
15970562
[Indexed for MEDLINE]

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