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Early Hum Dev. 2005 Jul;81(7):643-6.

Quantification of L-type fatty acid binding protein in the urine of preterm neonates.

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Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui 910-1193, Japan.


We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2'-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.

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