Format

Send to

Choose Destination
See comment in PubMed Commons below
Therapie. 2005 Mar-Apr;60(2):175-81.

[Assessment of renal abnormalities in 107 HIV patients treated with tenofovir].

[Article in French]

Author information

1
Service des Maladies Infectieuses et Tropicales, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier, France.

Abstract

OBJECTIVES:

The objectives of our study were to assess frequency, severity and outcome of renal abnormalities, as well as to determine the risk of developing hypophosphataemia in HIV-infected patients receiving tenofovir.

METHODS:

An observational study was conducted in real-life conditions, during a 6-month period, in 107 HIV patients receiving tenofovir.

RESULTS:

Mild-to-moderate hypophosphataemia (<0.77 mmol/L) occurred during follow-up, at least once in 43% of patients and at least twice in 27%. Antiretroviral therapy including ritonavir + lopinavir was significantly associated with the occurrence of hypophosphataemia (relative risk = 2.6; p = 0.03). Frequency of abnormal proteinuria was 22%.

CONCLUSION:

Creatinine clearance, phosphataemia, proteinuria and glycosuria should be closely monitored in patients receiving tenofovir therapy.

PMID:
15969320
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center