Format

Send to

Choose Destination
Cell Mol Life Sci. 2005 Aug;62(15):1707-23.

Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.

Author information

1
Center for Advanced Science and Innovation, Osaka University, Suita, Osaka, 565-0871, Japan.

Abstract

Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional techniques to prevent tyrosinase action encourages us to seek new potent tyrosinase inhibitors. This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance.

PMID:
15968468
DOI:
10.1007/s00018-005-5054-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center