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Br J Rheumatol. 1992 Jun;31(6):405-8.

A preliminary study on the effect of alpha-interferon treatment on the joint inflammation and serum calcium in rheumatoid arthritis.

Author information

1
Department of Medicine, Kobe University School of Medicine, Japan.

Abstract

A 12-week, double-blind controlled study comparing low dose alpha-interferon (5 x 10(5) iu, twice a week) and placebo was carried out to determine whether this drug has an immunomodulatory effect in rheumatoid arthritis. There were statistically significant improvements in the patients' joint score, C-reactive protein value and platelet count, without any side effects. Interferon-alpha caused an increase of serum calcium and a decrease of alkaline phosphatase. Thus, alpha-interferon requires further investigation as a possible additional useful treatment for rheumatoid arthritis.

PMID:
1596703
DOI:
10.1093/rheumatology/31.6.405
[Indexed for MEDLINE]

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