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Retrovirology. 2005 Jun 20;2:40.

TRIM5alpha selectively binds a restriction-sensitive retroviral capsid.

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Department of Microbiology, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, HHSC 1502, New York, New York 10032, USA.


TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the alpha-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5alpha binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.

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