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BMC Neurol. 2005 Jun 20;5:11.

Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients.

Author information

1
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A1000, Bethesda, MD 20892, USA. clarimon@mail.nih.gov

Abstract

BACKGROUND:

Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations.

METHODS:

Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland.

RESULTS:

No association was found in any of the populations studied.

CONCLUSION:

Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.

PMID:
15967032
PMCID:
PMC1183215
DOI:
10.1186/1471-2377-5-11
[Indexed for MEDLINE]
Free PMC Article

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