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Swiss Med Wkly. 2005 Apr 30;135(17-18):243-51.

Prosthetic joint infections: update in diagnosis and treatment.

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Division of Infectious diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland.


The pathogenesis of prosthetic joint infection is related to microorganisms growing in biofilms, rendering these infections difficult to diagnose and to eradicate. Low-grade infections in particular are difficult to distinguish from aseptic failure, often presenting only with early loosening and persisting pain, or no clinical signs of infection at all. A combination of preoperative and intraoperative tests is usually needed for an accurate diagnosis of infection of prosthetic joint infections. Successful treatment requires adequate surgical procedure combined with long-term antimicrobial therapy, ideally with an agent acting on adhering stationary- phase microorganisms. In this article, epidemiology, pathogenesis, diagnosis and treatment of prosthetic joint infections are reviewed.

[Indexed for MEDLINE]

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