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J Biol Chem. 2005 Aug 19;280(33):29506-12. Epub 2005 Jun 17.

Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences.

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1
Max Planck Institute for Experimental Medicine, Göttingen, Germany.

Abstract

N-Linked glycosylation is a common post-translational modification of membrane proteins. Here we report that mature Eag1 potassium channels carry sugar moieties linked to asparagines at positions 388 and 406. Asn-388 seems to undergo only core glycosylation, but complex sugars are bound to Asn-406. Correct complex glycosylation is required for proper trafficking of Eag1 to the plasma membrane but is also crucial for the correct function of channels already inserted in the membrane.

PMID:
15964838
DOI:
10.1074/jbc.M504228200
[Indexed for MEDLINE]
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