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Addict Behav. 2006 Mar;31(3):537-43. Epub 2005 Jun 17.

Ability of a new oral nicotine substitute to reduce smoking urge in moderate smokers.

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FORENAP Research Institute for Neuroscience, Pharmacology and Psychiatry, 27 rue du 4eme RSM, 68250 Rouffach, France.


The aim of this study was to assess the effectiveness of a new nicotine lozenge ( Nicopass 1.5 mg) in reducing smoking urge after an overnight abstinence. Twenty-four moderate smokers participated in a randomized, double-blind, placebo-controlled, 2-period crossover trial. The results showed that 1.5 mg-nicotine lozenge is superior to placebo in reducing smoking urge (p = 0.0001). In addition, nicotine lozenge, but not placebo, significantly improved vigilance and psychomotor performances (p < 0.05) and displayed a cardiac chronotropic effect. Thus, the 1.5-mg nicotine lozenge appears as an effective aid to alleviate acute tobacco withdrawal symptoms in moderate smokers.

[Indexed for MEDLINE]

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