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Eur J Pharmacol. 2005 Jun 15;516(3):247-52.

Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret.

Author information

1
Emesis Research Group, Department of Pharmacology and Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, PR China.

Abstract

The action of domperidone (1 mg/kg, i.p.) on spontaneous behaviour and the emesis and behavioural change induced by apomorphine (0.25 mg/kg, s.c.) were studied in the ferret. Domperidone was inactive to modify spontaneous behaviour but apomorphine-induced emesis and increased locomotor activity (distance travelled and velocity of movement; P<0.05); the emesis, but not the modification of locomotor activity was antagonized significantly (P<0.01) by domperidone. However, apomorphine did not modify significantly other behavioural measures (i.e. lip licking, rearing, burrowing, backward walking, curling-up activity, or defecatory frequency; P>0.05). The action of apomorphine to modify behaviour and its interaction with domperidone in this species is discussed in relation to animal models of nausea.

PMID:
15963978
DOI:
10.1016/j.ejphar.2005.05.028
[Indexed for MEDLINE]

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