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Eur J Pharmacol. 2005 Jun 15;516(3):247-52.

Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret.

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Emesis Research Group, Department of Pharmacology and Department of Anatomy, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, PR China.


The action of domperidone (1 mg/kg, i.p.) on spontaneous behaviour and the emesis and behavioural change induced by apomorphine (0.25 mg/kg, s.c.) were studied in the ferret. Domperidone was inactive to modify spontaneous behaviour but apomorphine-induced emesis and increased locomotor activity (distance travelled and velocity of movement; P<0.05); the emesis, but not the modification of locomotor activity was antagonized significantly (P<0.01) by domperidone. However, apomorphine did not modify significantly other behavioural measures (i.e. lip licking, rearing, burrowing, backward walking, curling-up activity, or defecatory frequency; P>0.05). The action of apomorphine to modify behaviour and its interaction with domperidone in this species is discussed in relation to animal models of nausea.

[Indexed for MEDLINE]

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