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Mol Ther. 2005 Jul;12(1):18-27.

GM-CSF gene-transduced tumor vaccines.

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1
Mary Crowley Medical Research Center/Texas Oncology PA, Dallas, TX 75201, USA.

Abstract

GVAX is a GM-CSF gene-transduced tumor vaccine. Expression of the GM-CSF gene within either autologous or allogeneic tumor cell populations has demonstrated evidence of immune stimulation in patients and evidence of antitumor activity particularly in prostate cancer and non-small-cell lung cancer. Results of preclinical studies justify clinical investigation. A summary of clinical results is presented.

PMID:
15963916
DOI:
10.1016/j.ymthe.2005.02.012
[Indexed for MEDLINE]
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