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Eur Neuropsychopharmacol. 2005 Aug;15(4):473-90.

Prevalence and incidence of Parkinson's disease in Europe.

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1
Department of Neurology, Friedrich-Wilhelms-University, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

Abstract

OBJECTIVE:

To provide an overview on the prevalence and incidence of Parkinson's disease (PD) in selected European countries.

BACKGROUND:

PD is a common disease of unknown etiology. Accurate information on the epidemiology of PD is critical to inform health policy. An aging population will lead to more patients with PD; thus, the high financial burden PD places on society will increase.

MATERIAL AND METHODS:

A systematic literature search was performed to identify studies on the prevalence and incidence of PD in the following European countries: Austria, the Czech Republic, France, Germany, Italy, The Netherlands, Portugal, Spain, Sweden and United Kingdom. Only published studies were included. Abstracts, reviews, meta-analyses and letters to the editor were excluded. There were no language restrictions. Data were extracted using a standardized assessment form, and evidence tables were used to systematically report and compare the data.

RESULTS:

Of 39 identified studies, most (87%) reported estimates of PD prevalence rates, while only a few (13%) reported estimates of PD annual incidence rates. Crude prevalence rate estimates ranged from 65.6 per 100,000 to 12,500 per 100,000 and annual incidence estimates ranged from 5 per 100,000 to 346 per 100,000. No publications could be identified for Austria or the Czech Republic.

DISCUSSION AND CONCLUSION:

The observed variations in prevalence and incidence rates may result from environmental or genetic factors, but might also be a consequence of differences in methodologies for case ascertainment, diagnostic criteria, or age distributions of the study populations. The comparability of existing studies is limited.

PMID:
15963700
DOI:
10.1016/j.euroneuro.2005.04.007
[Indexed for MEDLINE]
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