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Curr Opin Immunol. 1992 Feb;4(1):3-7.

Antibiotic peptides as mediators of innate immunity.

Author information

1
Children's Hospital of Philadelphia.

Abstract

Antibiotic peptides are widely distributed in nature. Almost all function as membrane-active agents, disrupting target-cell permeability. Several exhibit a striking selectivity for single-celled microbes over metazoan cells, and as such are amongst the simplest components of the animal's defensive system, which distinguishes environmental microbes from 'self'.

PMID:
1596366
[Indexed for MEDLINE]

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