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Emerg Infect Dis. 2005 Jun;11(6):829-37.

Community prescribing and resistant Streptococcus pneumoniae.

Author information

1
Soroka University Medical Center and Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Abstract

We investigated the association between prescribing antimicrobial agents and antimicrobial resistance of Streptococcus pneumoniae among children with acute otitis media in southern Israel. During a 6-year period, all prescriptions of a sample of approximately 20% of Jewish and Bedouin children <5 years of age were recorded and all pneumococcal isolates from middle ear fluid were collected. Although antimicrobial drug use was significantly higher in Bedouin children, the proportion of S. pneumoniae isolates with penicillin MIC = or > 1.0 microg/mL was significantly higher in Jewish children. In both populations, antimicrobial prescriptions were markedly reduced over time, especially for penicillins and erythromycin. In contrast, azithromycin prescriptions increased from 1998 to 2001 with a parallel increase in macrolide and multidrug resistance. Penicillin resistance was associated with macrolide resistance. These findings strongly suggest that azithromycin affects increased antimicrobial resistance, including multidrug resistance, in S. pneumoniae.

PMID:
15963276
PMCID:
PMC3367585
DOI:
10.3201/eid1106.050198
[Indexed for MEDLINE]
Free PMC Article

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