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Aliment Pharmacol Ther. 2005 Jul 1;22(1):31-5.

Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth.

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1
Internal Medicine Department, Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy.

Abstract

BACKGROUND:

Few controlled studies assessing choice and duration of antibiotic therapy for small intestinal bacterial overgrowth are available.

AIM:

To assess efficacy, safety and tolerability of different doses of rifaximin, a broad spectrum non-absorbable antibiotic, for intestinal bacterial overgrowth eradication.

METHODS:

We enrolled 90 consecutive patients affected by small intestinal bacterial overgrowth. The presence of small intestinal bacterial overgrowth was based on the occurrence of a rise of H2 values >12 p.p.m. above the basal value after 50 g glucose ingestion. Patients were randomized in three 7-day treatment groups: rifaximin 600 mg/day (group 1); rifaximin 800 mg/day (group 2) and rifaximin 1200 mg/day (group 3). Glucose breath test was reassessed 1 month after the end of therapy. Compliance to the treatment and incidence of side-effects were also evaluated.

RESULTS:

No drop-outs were observed in the three groups. Glucose breath test normalization rate was significantly higher in group 3 (60%) with respect to group 1 (17%; P < 0.001) and group 2 (27%, P < 0.01). No significant differences in patient compliance and incidence of side-effects were found among groups.

CONCLUSIONS:

Higher doses of rifaximin lead to a significant gain in terms of therapeutic efficacy in small intestinal bacterial overgrowth eradication without increasing the incidence of side-effects.

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