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Arthritis Res Ther. 2005;7 Suppl 3:S9-12. Epub 2005 May 18.

B cells in rheumatoid synovitis.

Author information

1
Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia, USA. cweyand@emory.edu

Abstract

In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals.

PMID:
15960820
PMCID:
PMC2833971
DOI:
10.1186/ar1737
[Indexed for MEDLINE]
Free PMC Article
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