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Int J Colorectal Dis. 2006 Apr;21(3):201-8. Epub 2005 Jun 16.

The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence.

Author information

1
University Department of Surgery, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.

Abstract

OBJECTIVE:

The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy.

MATERIALS AND METHODS:

Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.

RESULTS:

The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.

CONCLUSION:

Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

PMID:
15959790
DOI:
10.1007/s00384-005-0776-8
[Indexed for MEDLINE]

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