Format

Send to

Choose Destination
Biochem Cell Biol. 2005 Jun;83(3):332-43.

Many players, one goal: how chromatin states are inherited during cell division.

Author information

1
Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg, Germany. r.santoro@DKFZ-Heidelberg.de

Abstract

Replication of genomic material is a process that requires not only high fidelity in the duplication of DNA sequences but also inheritance of the chromatin states. In the last few years enormous effort has been put into elucidating the mechanisms involved in the correct propagation of chromatin states. From all these studies it emerges that an epigenetic network is at the base of this process. A coordinated interplay between histone modifications and histone variants, DNA methylation, RNA components, ATP-dependent chromatin remodeling, and histone-specific assembly factors regulates establishment of the replication timing program, initiation of replication, and propagation of chromatin domains. The aim of this review is to examine, in light of recent findings, how so many players can be coordinated with each other to achieve the same goal, a correct inheritance of the chromatin state.

PMID:
15959559
DOI:
10.1139/o05-021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center