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AIDS. 2005 Jul 1;19(10):1091-6.

SEN virus has an adverse effect on the survival of HIV-positive patients.

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Clinic for Gastroenterology, Hepatology and Infections bInstitute of Virology, University of Düsseldorf, Düsseldorf, Germany.



Patients infected with HIV are often coinfected with other viruses.


To investigate the effect of SEN virus (SENV) strains D and H on mortality in HIV-positive patients.


A total of 217 HIV-positive patients were analysed retrospectively after first presentation and blood sampling (January 1997 to July 1997) and the effect of coinfection with SENV-D and SENV-H on survival was examined. Analysis periods were the time from blood sampling to the end of follow-up, and the time from diagnosis of HIV infection to the end of study follow-up. SENV-H DNA was measured quantitatively. Prevalences of SENV-D and SENV-H were compared with those in 112 healthy blood donors.


SENV prevalence was significantly higher in HIV-positive patients than in controls (56/217 and 12/112, respectively; P < 0.001). SENV positivity had no influence on survival, but a significant negative influence of SENV-H on survival was observed when SENV-H DNA was > 530 copies/ml, which was the mean SENV-H DNA level found in HIV-negative controls. This adverse effect was found for both studied time periods in a Kaplan-Meier analyses. A multivariate Cox regression analysis, including CD4 cell count, Centers for Disease Control and Prevention stage, age, sex, HIV RNA, highly active antiretroviral therapy and hepatitis C virus status, revealed that a high SENV DNA level was an independent risk factor or indicator for adverse disease outcome.


SENV infection is common in HIV-positive patients. High SENV-H DNA levels were predictive for poor survival in HIV-positive patients.

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