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Org Lett. 2005 Jun 23;7(13):2751-4.

Convergent synthesis of a complex oxime library using chemical domain shuffling.

Author information

1
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.

Erratum in

  • Org Lett. 2005 Jul 21;7(15):3391.

Abstract

[reaction: see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.

PMID:
15957938
DOI:
10.1021/ol051023r
[Indexed for MEDLINE]

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