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Diabetes Res Clin Pract. 2005 Jul;69(1):29-35. Epub 2004 Dec 30.

Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6.

Author information

1
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea. hyesoon@amc.seoul.kr

Abstract

OBJECTIVE:

To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, and obesity and visceral adiposity.

METHODS:

A cross-sectional study of 100 Korean adults free from pre-existing inflammatory disease or cancer was performed. Body mass index (BMI), waist circumference, and serum concentrations of CRP, TNF-alpha and IL-6 were measured. In 46 obese subjects, fat mass was assessed by bioimpedance analysis and abdominal fat distribution was determined by computerized tomography scan.

RESULTS:

Overall, serum concentrations of CRP, TNF-alpha and IL-6 were significantly correlated with weight, BMI, waist circumference, hip circumference, and waist-hip ratio. In obese subjects, CRP and IL-6 were significantly correlated with BMI, waist circumference and visceral adipose tissue. Multiple regression analysis showed that CRP was significantly associated with BMI, whereas IL-6 was significantly related with visceral adiposity in obese subjects.

CONCLUSIONS:

The positive associations of obesity and visceral adiposity with elevated cytokine levels suggest the importance of reducing obesity and visceral adiposity to prevent elevations in cytokine levels.

PMID:
15955385
DOI:
10.1016/j.diabres.2004.11.007
[Indexed for MEDLINE]

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