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Biochem J. 2005 Jul 1;389(Pt 1):1-11.

Ras plasma membrane signalling platforms.

Author information

1
Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia. j.hancock@imb.uq.edu.au

Abstract

The plasma membrane is a complex, dynamic structure that provides platforms for the assembly of many signal transduction pathways. These platforms have the capacity to impose an additional level of regulation on cell signalling networks. In this review, we will consider specifically how Ras proteins interact with the plasma membrane. The focus will be on recent studies that provide novel spatial and dynamic insights into the micro-environments that different Ras proteins utilize for signal transduction. We will correlate these recent studies suggesting Ras proteins might operate within a heterogeneous plasma membrane with earlier biochemical work on Ras signal transduction.

PMID:
15954863
PMCID:
PMC1184533
DOI:
10.1042/BJ20050231
[Indexed for MEDLINE]
Free PMC Article

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