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Nat Med. 2005 Jul;11(7):740-7. Epub 2005 Jun 12.

Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.

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1
Animal Models & Retroviral Vaccines Section, National Cancer Institute, 41/D804, Bethesda, Maryland 20892, USA.

Abstract

Vaccination with live vaccinia virus affords long-lasting protection against variola virus, the agent of smallpox. Its mode of protection in humans, however, has not been clearly defined. Here we report that vaccinia-specific B-cell responses are essential for protection of macaques from monkeypox virus, a variola virus ortholog. Antibody-mediated depletion of B cells, but not CD4+ or CD8+ T cells, abrogated vaccine-induced protection from a lethal intravenous challenge with monkeypox virus. In addition, passive transfer of human vaccinia-neutralizing antibodies protected nonimmunized macaques from severe disease. Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax).

PMID:
15951823
DOI:
10.1038/nm1261
[Indexed for MEDLINE]
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