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Bioorg Med Chem Lett. 2005 Aug 15;15(16):3685-90.

Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12790 El Camino Real, San Diego, CA 92130, USA. zguo@neurocrine.com

Abstract

SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.

PMID:
15951171
DOI:
10.1016/j.bmcl.2005.05.038
[Indexed for MEDLINE]

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