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Eur J Med Chem. 2005 Nov;40(11):1087-95. Epub 2005 Jun 13.

Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.

Author information

1
Institut de Chimie Organique et Analytique, UMR 6005, Université d'Orléans, B.P. 6759, 45067 Orléans cedex 2, France.

Abstract

A series of 2,5- and 3,5-diphenylpyridine derivatives was synthetised in high yields. A versatile chemical strategy allows the design of diphenylpyridines differently substituted with cationic or neutral side chains. The interaction of the molecules with DNA was investigated by biophysical and biochemical methods and an AT-binder (20) was characterised. A few cytotoxic molecules were identified but their antiproliferative activity does not correlate with DNA binding. Two compounds 18 and 22 showed significant antiproliferative activity and provide a novel route to potential anticancer agents.

PMID:
15951061
DOI:
10.1016/j.ejmech.2005.04.011
[Indexed for MEDLINE]

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