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Biochem Biophys Res Commun. 2005 Jul 29;333(2):470-5.

IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression.

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1
Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA, Los Angeles, CA, USA.

Abstract

COX-2 overexpression and subsequent PGE(2) production are frequently associated with non-small cell lung cancer and are implicated in tumor-mediated angiogenesis. Here, we report for the first time that IL-20 downregulates COX-2 and PGE(2) in human bronchial epithelial and endothelial cells. Flow cytometry analysis suggests that IL-20-dependent inhibition of COX-2/PGE(2) occurs through the IL-22R1/IL-20R2 dimers. In addition, we report that IL-20 exerts anti-angiogenic effects, inhibiting experimental angiogenesis. IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway. Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE(2) and inhibits angiogenesis.

PMID:
15950941
DOI:
10.1016/j.bbrc.2005.05.122
[Indexed for MEDLINE]
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