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Cancer Cell. 2005 Jun;7(6):499-500.

Coevolution of cancer and stromal cellular responses.

Author information

1
Department of Anatomy, University of California, San Francisco, CA 94143, USA.

Abstract

It is now becoming apparent that multiple types of stromal cells, including macrophages, mast cells, adipocytes, and fibroblasts make pivotal contributions to carcinogenesis. In the May 6 issue of Cell, Orimo and colleagues (Orimo et al., 2005) show that carcinoma-associated fibroblasts can promote epithelial tumorigenesis by secreting the chemokine SDF-1alpha (CXCL12). SDF-1alpha stimulates carcinoma cell proliferation and recruitment of endothelial precursor cells.

PMID:
15950897
DOI:
10.1016/j.ccr.2005.05.019
[Indexed for MEDLINE]
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