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Am J Cardiol. 2005 Jun 15;95(12):1456-9.

Longevity of the placebo effect in the therapeutic angiogenesis and laser myocardial revascularization trials in patients with coronary heart disease.

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1
Angiogenesis Research Center and Division of Cardiology and Cardiac Surgery, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

Abstract

The long-term beneficial effects of placebo therapy were evaluated in angiogenesis and laser myocardial revascularization trials in patients who had end-stage coronary heart disease. Improvements in mean angina class, exercise treadmill time, and quality of life were mostly maintained at 30 +/- 6 months of follow-up. Persistence of effect cannot be used as evidence of efficacy, and double-blinded trials are essential in this patient population.

PMID:
15950570
DOI:
10.1016/j.amjcard.2005.02.013
[Indexed for MEDLINE]
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