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Trends Genet. 2005 Jul;21(7):367-70.

Sex determination: a tale of two Sox genes.

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1
Division of Molecular Genetics and Developmental Biology, and ARC Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia. p.koopman@imb.uq.edu.au

Abstract

Vertebrates use many different strategies to determine sex, but the Sox9 gene is a common thread, probably acting as the pivotal gene that controls the male-determining pathway. It now appears that Sox9 is not alone in this role, and that a closely related gene, Sox8, can partly substitute for Sox9. But is this a clever backup strategy to safeguard male development, or a relic of the past?

PMID:
15949865
DOI:
10.1016/j.tig.2005.05.006
[Indexed for MEDLINE]
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