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Mol Cell. 2005 Jun 10;18(6):617-22.

Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair.

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1
Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York 14642, USA.

Abstract

A bevy of recent reports have firmly established a mechanistic link between a histone posttranslational modification associated with DNA double-strand breaks and recruitment of chromatin-modifying activities. These papers show that in addition to providing signals for transcriptional regulation, specific histone "codes" can coordinate and target multiple activities involved in DNA repair.

PMID:
15949437
DOI:
10.1016/j.molcel.2005.05.008
[Indexed for MEDLINE]
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