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Br J Dermatol. 2005 Jun;152(6):1316-20.

The calcium-binding protein calretinin is a marker of the companion cell layer of the human hair follicle.

Author information

1
Dermatology of Pathology, Hospital General Universitario de Albacete and Universidad de Castilla La Mancha, Spain.

Abstract

BACKGROUND:

Ultrastructural studies of the hair follicle show that the outer root sheath (ORS) does not consist of a homogeneous cell population. The innermost cell layer of the ORS, also called the companion layer, is a single cell layer closely associated with the Henle layer of the inner root sheath.

OBJECTIVES:

To describe the immunohistochemical expression of calretinin, a calcium-binding protein, in the human hair follicle.

METHODS:

Immunohistochemical studies using two different antisera to calretinin were performed in paraffin-embedded and in frozen scalp specimens using standard techniques.

RESULTS:

Calretinin immunostaining was consistently and specifically found in the companion cell layer of hair follicles.

CONCLUSIONS:

These findings provide further evidence to support the notion that the companion layer is not only morphologically, but also immunohistochemically, different from the other cells of the ORS.

[Indexed for MEDLINE]

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